Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26194061 | 0.84 | ALDH1A1 (0.34) | TSHR | |
| SCHEMBL21146102 | 0.82 | — | — | |
| SCHEMBL627811 | 0.80 | ALDH1A1 (0.52) | TSHR | |
| SCHEMBL799639 | 0.75 | MEN1 (0.35) | MEN1KMT2ATSHR | |
| SCHEMBL358641 | 0.73 | — | — | |
| SCHEMBL12371957 | 0.73 | — | — | |
| SCHEMBL17426947 | 0.73 | TSHR (0.37) | MEN1KMT2ATSHR | |
| SCHEMBL22215204 | 0.71 | TSHR (0.40) | MEN1KMT2ATSHR | |
| SCHEMBL303817 | 0.69 | MEN1 (0.40) | MEN1KMT2A | |
| SCHEMBL868378 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071575-B1 | PREPARATION OF NORMORPHINANS | SpecGx LLC (US) | 2019-11-13 | — | — | EP | claimed |
| US-10246481-B2 | Bile acid derivatives and methods for synthesis and use | CITY OF HOPE (US) | 2019-04-02 | — | — | US | claimed |
| US-20180319836-A1 | BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE | HOPE CITY (US) | 2018-11-08 | — | — | US | claimed |
| US-20170233431-A1 | BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE | HOPE CITY (US) | 2017-08-17 | — | — | US | claimed |
| EP-3071575-A1 | PREPARATION OF NORMORPHINANS | Mallinckrodt LLC (US) | 2016-09-28 | — | — | EP | claimed |
| US-9127009-B2 | Preparation of normorphinans | MALLINCKRODT LLC | 2015-09-08 | — | — | US | claimed |
| WO-2015074049-A1 | PREPARATION OF NORMORPHINANS | MALLINCKRODT LLC (US) | 2015-05-21 | — | — | WO | claimed |
| US-20150141649-A1 | PREPARATION OF NORMORPHINANS | VTESSE LLC | 2015-05-21 | — | — | US | claimed |
| CN-102869696-B | Hybrid polyester-polyether polyols | DOW GLOBAL TECHNOLOGIES LLC | 2015-02-04 | — | — | CN | claimed |
| US-20140206657-A1 | BILE ACID ANALOG TGR5 AGONISTS | CITY OF HOPE (US) | 2014-07-24 | — | — | US | claimed |
| US-8491790-B2 | Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabelling without any evaporation step by the use of strong organic bases | TRASIS S.A. (BE) | 2013-07-23 | — | — | US | claimed |
| EP-2164590-B1 | METHOD FOR THE DIRECT ELUTION OF REACTIVE 18F FLUORIDE FROM AN ANION EXCHANGE RESIN IN AN ORGANIC MEDIUM SUITABLE FOR RADIOLABELLING WITHOUT ANY EVAPORATION STEP BY THE USE OF STRONG ORGANIC BASES | TRASIS S A (BE) | 2013-03-06 | — | — | EP | claimed |
| EP-2563834-A1 | HYBRID POLYESTER-POLYETHER POLYOLS | Dow Global Technologies LLC (US) | 2013-03-06 | — | — | EP | claimed |
| US-20130035467-A1 | HYBRID POLYESTER-POLYETHER POLYOLS | DOW EUROPE GMBH (CH) | 2013-02-07 | — | — | US | claimed |
| CN-102869696-A | Hybrid polyester-polyether polyols | DOW GLOBAL TECHNOLOGIES LLC | 2013-01-09 | — | — | CN | claimed |
| WO-2011137011-A1 | HYBRID POLYESTER-POLYETHER POLYOLS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-11-03 | — | — | WO | claimed |
| US-20100196254-A1 | METHOD FOR THE DIRECT ELUTION OF REACTIVE 18F FLUORIDE FROM AN ANION EXCHANGE RESIN IN AN ORGANIC MEDIUM SUITABLE FOR RADIOLABELLING WITHOUT ANY EVAPORATION STEP BY THE USE OF STRONG ORGANIC BASES | TRASIS S.A. (BE) | 2010-08-05 | — | — | US | claimed |
| EP-2062630-A1 | Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium by the use of strong organic bases | Trasis S.A. (BE) | 2009-05-27 | — | — | EP | claimed |
| US-20090087753-A1 | VOLUME PHASE HOLOGRAM RECORDING MATERIAL, PRODUCTION PROCESS THEREFOR, AND RECORDED MATERIAL | TOAGOSEI CO., LTD. (JP) | 2009-04-02 | — | — | US | claimed |
| EP-1906265-A1 | VOLUME PHASE HOLOGRAM RECORDING MATERIAL, PROCESS FOR PRODUCING THE SAME, AND RECORDED MATERIAL | TOAGOSEI CO., LTD. (JP) | 2008-04-02 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141649-A1 | PREPARATION OF NORMORPHINANS | OPRL1, APLNR, OPRM1 | MEN1 590/4885KMT2A 2337/4885TSHR 975/4885 |
| US-20170233431-A1 | BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE | NR1H4, GPBAR1, SLC10A1 | MEN1 4390/4885KMT2A 4246/4885TSHR 669/4885 |
| US-10246481-B2 | Bile acid derivatives and methods for synthesis and use | NR1H4, GPBAR1, SLC10A1 | MEN1 4390/4885KMT2A 4246/4885TSHR 669/4885 |
| US-20140206657-A1 | BILE ACID ANALOG TGR5 AGONISTS | GPBAR1, NR1H4, SLC10A1 | MEN1 4352/4885KMT2A 4521/4885TSHR 128/4885 |
| US-20180319836-A1 | BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE | NR1H4, GPBAR1, SLC10A1 | MEN1 4390/4885KMT2A 4246/4885TSHR 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.