Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137434 | 0.83 | HTR6 (0.60) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7138902 | 0.82 | ALDH1A1 (0.47) | HTR6HSP90AA1MAPTALDH1A1RAB9A | |
| SCHEMBL7141934 | 0.82 | HTR6 (0.67) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7135361 | 0.75 | HTR6 (0.58) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7138620 | 0.75 | HTR6 (1.00) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7140761 | 0.75 | HTR6 (0.67) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7138609 | 0.73 | HTR6 (1.00) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL7137430 | 0.72 | HTR6 (0.58) | HTR6HTR2AHTR1DHTR2CCYP3A4 | |
| SCHEMBL9806707 | 0.72 | HTR6 (0.67) | HTR6CYP3A4CYP2C9LMNAMPO | |
| SCHEMBL7836526 | 0.72 | HTR6 (0.82) | HTR6CYP3A4CYP2C9LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | claimed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | claimed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | claimed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | claimed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | claimed |
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | disclosed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |