SCHEMBL7135385

SCHEMBL7135385

CO/C=C(/C(=O)O)c1ccccc1C=C/C=C/c1ccc(C(F)(F)F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.42
CYP1A1 P04798 3/20 0.40
CYP1B1 Q16678 3/20 0.40
MAOB P27338 3/20 0.40
NFE2L2 Q16236 1/20 0.40
NOS3 P29474 1/20 0.40
NOS1 P29475 1/20 0.40
NOS2 P35228 1/20 0.40
CYP1A2 P05177 1/20 0.40
NR1H3 Q13133 1/20 0.39
AKR1C3 P42330 1/20 0.38
HDAC3 O15379 1/20 0.37
ADAM17 P78536 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7135382 1.00 TRPA1 (0.42) TRPA1TRPM8CYP1A1CYP1B1MAOB
SCHEMBL7136435 0.91 TRPA1 (0.42) TRPA1TRPM8CYP1A1CYP1B1MAOB
SCHEMBL7135398 0.89 TRPV1 (0.41) MAOBCYP1A2NR1H3TRPV1
SCHEMBL7135393 0.89 TRPV1 (0.41) MAOBCYP1A2NR1H3TRPV1
SCHEMBL7144373 0.88 MAOB (0.44) MAOBNFE2L2
SCHEMBL7144375 0.88 MAOB (0.44) MAOBNFE2L2
SCHEMBL7139096 0.88 MAOB (0.42) TRPA1MAOBNFE2L2CYP1A2HDAC3
SCHEMBL7139094 0.88 MAOB (0.42) TRPA1MAOBNFE2L2CYP1A2HDAC3
SCHEMBL7140080 0.87 TUBB4A (0.40) TRPA1MAOBNFE2L2
SCHEMBL7140078 0.87 TUBB4A (0.40) TRPA1MAOBNFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0996439-B1 BETA-ALKOXYACRYLATES AGAINST MALARIA HOFFMANN LA ROCHE (CH) 2003-01-08 EP claimed
US-6084120-A ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID HOFFMANN-LA ROCHE INC. (US) 2000-07-04 US claimed
EP-0996439-B1 BETA-ALKOXYACRYLATES AGAINST MALARIA HOFFMANN LA ROCHE (CH) 2003-01-08 EP disclosed