Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | G6PD | P11413 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362932 | 0.84 | ERBB2 (0.49) | KMT2AMEN1ALPLHSP90AA1ALPI | |
| SCHEMBL7139474 | 0.81 | MAPT (0.42) | KMT2AMEN1ALPLHSP90AA1ALPI | |
| SCHEMBL5358279 | 0.79 | KMT2A (0.38) | KMT2AMEN1ALPLHSP90AA1ALPI | |
| SCHEMBL5365589 | 0.77 | KMT2A (0.51) | KMT2AMEN1SIRT1SIRT2SIRT3 | |
| SCHEMBL7135755 | 0.76 | KMT2A (0.53) | KMT2AMEN1ALPLHSP90AA1ALPI | |
| SCHEMBL5358437 | 0.76 | LRRK2 (0.49) | KMT2AMEN1POLBMAPK1LMNA | |
| SCHEMBL5361431 | 0.75 | METAP1 (0.54) | KMT2AMEN1MAPTSIRT1SIRT2 | |
| SCHEMBL5365774 | 0.75 | IKBKB (0.41) | KMT2AMEN1ALPIPOLBMAPT | |
| SCHEMBL7139388 | 0.75 | MAPT (0.55) | KMT2AMEN1POLBPKMMAPT | |
| SCHEMBL13587016 | 0.75 | MEN1 (0.76) | KMT2AMEN1ALPLHSP90AA1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |