Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136014 | 0.81 | KMT2A (0.56) | MAPTPOLBALDH1A1KMT2AXBP1 | |
| SCHEMBL5358279 | 0.79 | KMT2A (0.38) | MAPTPOLBALDH1A1KMT2AXBP1 | |
| SCHEMBL7139388 | 0.77 | MAPT (0.55) | MAPTPOLBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7139714 | 0.77 | MAPT (0.40) | MAPTPOLBSTAT3SMN1; SMN2ALDH1A1 | |
| SCHEMBL5365589 | 0.77 | KMT2A (0.51) | KMT2ARETSIRT1SIRT2SIRT3 | |
| SCHEMBL5362932 | 0.76 | ERBB2 (0.49) | MAPTPOLBALDH1A1KMT2AXBP1 | |
| SCHEMBL5358437 | 0.75 | LRRK2 (0.49) | POLBSMN1; SMN2KMT2AMAPK1RET | |
| SCHEMBL7135671 | 0.75 | SIRT1 (0.46) | MAPTALDH1A1KMT2AXBP1MAPK1 | |
| SCHEMBL7131372 | 0.74 | SIRT1 (0.48) | MAPTPOLBKMT2AMAPK1RET | |
| SCHEMBL5361431 | 0.74 | METAP1 (0.54) | MAPTKMT2ARETSIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |