Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365589 | 0.82 | KMT2A (0.51) | KMT2AMEN1SIRT1SIRT2SIRT3 | |
| SCHEMBL5358437 | 0.81 | LRRK2 (0.49) | POLBKMT2AMEN1SMN1; SMN2SIRT1 | |
| SCHEMBL5361431 | 0.80 | METAP1 (0.54) | MAPTKMT2AMEN1SIRT1SIRT2 | |
| SCHEMBL5377009 | 0.78 | CISD1 (0.48) | POLBKMT2AMEN1SIRT1SIRT2 | |
| SCHEMBL5361680 | 0.78 | SIRT2 (0.54) | KMT2AMEN1SIRT1SIRT2SIRT3 | |
| SCHEMBL7136821 | 0.78 | LRRK2 (0.51) | KMT2AMEN1SIRT1SIRT2SIRT3 | |
| SCHEMBL7137520 | 0.78 | ALDH1A1 (0.48) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL7134042 | 0.77 | MAPT (0.52) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL7131372 | 0.77 | SIRT1 (0.48) | MAPTPOLBKMT2AMEN1HPGD | |
| SCHEMBL7139474 | 0.77 | MAPT (0.42) | MAPTPOLBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |