Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | PPARA | Q07869 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136175 | 0.74 | PPARG (0.33) | PPARGPPARAPPARDSLC6A2SLC6A4 | |
| SCHEMBL2638524 | 0.74 | OPRL1 (0.35) | PPARGPPARA | |
| SCHEMBL7136179 | 0.73 | PPARG (0.33) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7144413 | 0.71 | SIGMAR1 (0.39) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7512388 | 0.70 | MEN1 (0.44) | TSHRMEN1KMT2AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7517078 | 0.70 | SIGMAR1 (0.38) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL22032844 | 0.70 | SIGMAR1 (0.48) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL18167506 | 0.69 | SIGMAR1 (0.47) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7517660 | 0.68 | L3MBTL1 (0.45) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7512579 | 0.68 | SIGMAR1 (0.36) | TSHRPPARGPPARASIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | claimed |
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |