Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | PPARA | Q07869 | 5/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136179 | 0.76 | PPARG (0.33) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7136172 | 0.74 | TSHR (0.35) | PPARGPPARAPPARDCYP2D6SLC6A2 | |
| SCHEMBL2638524 | 0.73 | OPRL1 (0.35) | PPARGPPARAMETAP2 | |
| SCHEMBL7144422 | 0.71 | SIGMAR1 (0.31) | METAP2CYP2D6 | |
| Hydrochloric Acid SCHEMBL7512395 | 0.70 | SLC6A2 (0.31) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7517090 | 0.70 | OPRK1 (0.32) | CYP2D6 | |
| Hydrochloric Acid SCHEMBL7512586 | 0.69 | PPARG (0.30) | PPARGPPARA | |
| SCHEMBL5213321 | 0.65 | ESR2 (0.45) | PPARGPPARACYP2D6 | |
| SCHEMBL7143023 | 0.64 | P2RX7 (0.32) | — | |
| SCHEMBL7136149 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | claimed |
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |