Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | NAT1 | P18440 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136076 | 0.87 | LRRK2 (0.42) | SIRT2SIRT1SIRT3LRRK2PSEN1 | |
| SCHEMBL7133826 | 0.85 | MAPT (0.44) | SIRT2SIRT1SIRT3DYRK1AALDH1A1 | |
| SCHEMBL7134007 | 0.85 | PIM1 (0.42) | SIRT2SIRT1SIRT3LRRK2PSEN1 | |
| SCHEMBL7131330 | 0.85 | ADAMTS5 (0.52) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL7138182 | 0.84 | KMT2A (0.42) | SIRT2SIRT1SIRT3PLK4ALDH1A1 | |
| SCHEMBL7138862 | 0.84 | MAPT (0.47) | SIRT2SIRT1SIRT3ALDH1A1MEN1 | |
| SCHEMBL8193593 | 0.82 | PLK4 (0.51) | LRRK2PLK4ALDH1A1MEN1KMT2A | |
| SCHEMBL7131272 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1SIRT3IGF1RALDH1A1 | |
| SCHEMBL7133405 | 0.82 | LRRK2 (0.46) | SIRT2SIRT1SIRT3IGF1RNAT1 | |
| SCHEMBL7133808 | 0.82 | DYRK1A (0.37) | SIRT2SIRT1SIRT3LRRK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |