Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | NAT1 | P18440 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134022 | 0.86 | LRRK2 (0.48) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5376959 | 0.85 | MAPT (0.44) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7134020 | 0.85 | LRRK2 (0.49) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7137562 | 0.85 | ADAMTS5 (0.52) | LRRK2 | |
| SCHEMBL7134014 | 0.83 | RET (0.48) | LRRK2IGF1RPLK4RETRAF1 | |
| SCHEMBL7136228 | 0.82 | SIRT2 (0.44) | LRRK2IGF1RPSEN1PSEN2APH1B | |
| SCHEMBL5363090 | 0.82 | LRRK2 (0.60) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7136802 | 0.82 | LRRK2 (0.43) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5366852 | 0.81 | LRRK2 (0.50) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7132867 | 0.81 | PDGFRB (0.55) | LRRK2IGF1RPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |