SCHEMBL7136262

SCHEMBL7136262

CN1CCC(=C2c3ccc(F)cc3CCn3ncnc32)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 2/20 0.43
SETD7 Q8WTS6 4/20 0.38
GABRG2 P18507 4/20 0.37
GABRB3 P28472 4/20 0.37
GABRA5 P31644 4/20 0.37
HRH1 P35367 4/20 0.36
CHRM2 P08172 3/20 0.36
HTR1A P08908 3/20 0.36
CHRM1 P11229 3/20 0.36
ADRA1A P35348 3/20 0.36
KCNH2 Q12809 3/20 0.36
DRD2 P14416 2/20 0.36
HTR2A P28223 2/20 0.36
HTR2C P28335 2/20 0.36
HTR2B P41595 2/20 0.36
OPRK1 P41145 1/20 0.36
SRD5A1 P18405 1/20 0.34
ADRA2A P08913 2/20 0.33
CYP2D6 P10635 2/20 0.33
DRD1 P21728 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7141253 0.87 PTAFR (0.38) PTAFRGABRG2GABRB3GABRA5HRH1
SCHEMBL7140008 0.85 DRD2 (0.43) PTAFRSETD7HRH1CHRM2HTR1A
SCHEMBL7136431 0.83 DRD1 (0.46) PTAFRSETD7GABRG2GABRB3GABRA5
SCHEMBL7141837 0.83 HRH1 (0.50) PTAFRGABRG2GABRB3GABRA5HRH1
Water SCHEMBL7140424 0.82 PTAFR (0.40) PTAFRGABRG2GABRB3GABRA5HRH1
SCHEMBL7136207 0.82 SETD7 (0.59) PTAFRSETD7HRH1CHRM2HTR1A
SCHEMBL7140680 0.82 PTAFR (0.40) PTAFRGABRG2GABRB3GABRA5HRH1
SCHEMBL7139726 0.81 HRH1 (0.38) PTAFRHRH1ADRA1AKCNH2DRD2
SCHEMBL9284701 0.81 SIGMAR1 (0.42) HRH1HTR1AADRA1ASLC6A4ADRA1D
SCHEMBL5056412 0.81 HRH1 (0.47) PTAFRSETD7HRH1CHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0675887-B1 ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2003-04-02 EP disclosed