Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136262 | 0.87 | PTAFR (0.43) | PTAFRHRH1HTR2CHTR2BCHRM2 | |
| SCHEMBL7138938 | 0.79 | HRH1 (0.42) | PTAFRHRH1HTR2CHTR2BMEN1 | |
| SCHEMBL7141837 | 0.78 | HRH1 (0.50) | PTAFRHRH1HTR2BMEN1LMNA | |
| SCHEMBL7136428 | 0.77 | GABRG2 (0.38) | PTAFRHTR2CHTR2BDRD2HTR2A | |
| Water SCHEMBL7140424 | 0.77 | PTAFR (0.40) | PTAFRHRH1HTR2CHTR2BDRD2 | |
| SCHEMBL7139726 | 0.76 | HRH1 (0.38) | PTAFRHRH1HTR2CHTR2BABCB1 | |
| SCHEMBL7140680 | 0.75 | PTAFR (0.40) | PTAFRHRH1DRD2DRD4DRD3 | |
| SCHEMBL7166986 | 0.74 | HRH1 (0.47) | HRH1MEN1KMT2AKCNH2 | |
| SCHEMBL9284701 | 0.74 | SIGMAR1 (0.42) | HRH1MEN1ABCB1HTR1ASLC6A4 | |
| SCHEMBL8208376 | 0.73 | HRH1 (0.37) | HRH1HTR2CLMNAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |