Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858277 | 0.88 | CA5A (0.59) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| SCHEMBL27949718 | 0.86 | CA5A (0.58) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| SCHEMBL9858012 | 0.80 | CYP2C19 (0.56) | CA5ACYP2C19ALDH1A1LMNAKDM4E | |
| Rufinamide SCHEMBL230448 | 0.79 | CA5A (1.00) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| Rufinamide SCHEMBL20769779 | 0.79 | CA5A (1.00) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| Rufinamide SCHEMBL17372728 | 0.78 | CA5A (0.97) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| SCHEMBL28478027 | 0.76 | CA5A (0.58) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| SCHEMBL8151152 | 0.76 | CA5A (0.73) | CA5ACYP2C19KLKB1ALDH1A1LMNA | |
| SCHEMBL11131522 | 0.75 | GPR55 (0.50) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL460913 | 0.74 | CA5A (0.76) | CA5ACYP2C19KLKB1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729729-B1 | PHARMACEUTICAL COMPOSITIONS | NOVARTIS AG (CH) | 2014-04-23 | — | — | EP | claimed |
| EP-0994864-B1 | CRYSTAL MODIFICATION OF 1-(2,6-DIFLUOROBENZYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE AND ITS USE AS ANTIEPILEPTIC | NOVARTIS PHARMA GMBH (AT) | 2003-04-16 | — | — | EP | disclosed |
| EP-0994863-B1 | CRYSTAL MODIFICATION OF 1-(2,6-DIFLUOROBENZYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE AND ITS USE AS ANTIEPILEPTIC | NOVARTIS AG (CH) | 2003-02-19 | — | — | EP | disclosed |
| EP-0994863-A1 | CRYSTAL MODIFICATION OF 1-(2,6-DIFLUOROBENZYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE AND ITS USE AS ANTIEPILEPTIC | Novartis AG (CH) | 2000-04-26 | — | — | EP | disclosed |
| EP-0994864-A1 | CRYSTAL MODIFICATION OF 1-(2,6-DIFLUOROBENZYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE AND ITS USE AS ANTIEPILEPTIC | Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. (AT) | 2000-04-26 | — | — | EP | disclosed |