Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405202 | 1.00 | TLR2 (0.31) | TLR2TLR1PTPN1PTPRC | |
| SCHEMBL5410587 | 0.90 | KIF11 (0.31) | — | |
| SCHEMBL7141662 | 0.90 | KIF11 (0.31) | — | |
| SCHEMBL7146717 | 0.83 | RAB9A (0.38) | — | |
| SCHEMBL5412644 | 0.83 | RAB9A (0.38) | — | |
| SCHEMBL5405198 | 0.78 | — | — | |
| SCHEMBL7139333 | 0.78 | — | — | |
| SCHEMBL7139336 | 0.78 | — | — | |
| SCHEMBL5411747 | 0.77 | SLC6A3 (0.35) | — | |
| SCHEMBL7147881 | 0.77 | SLC6A3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |