Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136764 | 0.89 | SMN1; SMN2 (0.42) | CTSKSMN1; SMN2CTSLCTSB | |
| SCHEMBL7134725 | 0.83 | CTSK (0.41) | CTSKCTSSSYKHDAC1 | |
| SCHEMBL7140706 | 0.83 | CTSK (0.40) | CTSKCTSSHDAC3HDAC1HDAC2 | |
| SCHEMBL7797057 | 0.81 | CTSK (0.42) | CTSKCTSSCTSLCTSBREN | |
| SCHEMBL7798639 | 0.79 | CTSK (0.44) | CTSKCTSSSMN1; SMN2SYKCTSL | |
| SCHEMBL7133729 | 0.79 | SMN1; SMN2 (0.42) | CTSKSMN1; SMN2CTSLCTSB | |
| SCHEMBL7139858 | 0.79 | CTSS (0.43) | CTSKCTSSCTSLCTSBREN | |
| SCHEMBL7136441 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2CTSLCTSB | |
| SCHEMBL7133720 | 0.78 | MEN1 (0.43) | CTSKCTSS | |
| SCHEMBL7130607 | 0.77 | SMN1; SMN2 (0.42) | CTSKSMN1; SMN2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506775-B1 | Treatment of a gastrointestinal disorder; a central nervous system (CNS) adverse conditions caused by Heliobacter pylori; or angiogenesis especially CNS disorders in a mammalian subject, especially humans. | PFIZER INC | 2003-01-14 | — | — | US | disclosed |