Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138342 | 0.89 | ALDH1A1 (0.53) | ERBB2PLK4EGFRKDM1ARET | |
| SCHEMBL7136802 | 0.87 | LRRK2 (0.43) | CCNE2CCNE1CDK2PLK4RET | |
| SCHEMBL7138253 | 0.87 | KDM1A (0.54) | PLK4KDM1ARETALDH1A1MAPT | |
| SCHEMBL5366009 | 0.85 | ERBB2 (0.62) | ERBB2PLK4EGFRKDM1ARET | |
| SCHEMBL7136184 | 0.84 | ERBB2 (0.43) | ERBB2PLK4EGFRTUBB1KDM1A | |
| SCHEMBL5357895 | 0.84 | IGF1R (0.53) | PLK4KDM1AALDH1A1MAPTKMT2A | |
| SCHEMBL5358747 | 0.83 | PLK4 (0.60) | ERBB2PLK4EGFRALDH1A1MAPT | |
| SCHEMBL7139913 | 0.80 | RAF1 (0.42) | PLK4EGFRRETMAPTKMT2A | |
| SCHEMBL7134866 | 0.80 | LRRK2 (0.50) | RETALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL7136994 | 0.79 | MAOA (0.44) | PLK4RETKMT2AMEN1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |