Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146679 | 0.88 | SRC (0.49) | SRCPTPN1FDPSALDH1A1MAPK1 | |
| SCHEMBL2680807 | 0.83 | ALDH1A1 (0.45) | FDPSALDH1A1MAPK1MEN1POLB | |
| SCHEMBL6738294 | 0.81 | SRC (0.49) | SRCMCL1FDPSALDH1A1MAPK1 | |
| SCHEMBL13573079 | 0.81 | ALDH1A1 (0.46) | SRCPTPN1FDPSALDH1A1MAPK1 | |
| SCHEMBL16055032 | 0.80 | ALDH1A1 (0.45) | FDPSALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL13116218 | 0.77 | SRC (0.42) | SRCFDPSALDH1A1MAPK1MEN1 | |
| SCHEMBL5989261 | 0.76 | FDPS (0.34) | SRCMCL1FDPSALDH1A1MAPK1 | |
| SCHEMBL4990719 | 0.74 | SRC (0.46) | SRCFDPSALDH1A1MAPK1MEN1 | |
| SCHEMBL4137984 | 0.74 | FDPS (0.43) | PTPN1FDPSALDH1A1MAPK1POLB | |
| SCHEMBL27426723 | 0.73 | ALDH1A1 (0.36) | SRCMCL1FDPSALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966464-B1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-05-28 | — | — | EP | disclosed |
| CN-1091109-C | Substituted 2, 4-diaminopyrimidines | BASLIER PHARMACEUTICALS AG (CH) | 2002-09-18 | — | — | CN | disclosed |
| US-6114330-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| CN-1249751-A | Substituted 2, 4-diaminopyrimidines | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | CN | disclosed |
| EP-0966464-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998039328-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-09-11 | — | — | WO | disclosed |