SCHEMBL714009

SCHEMBL714009

[c]1ccccc1-c1nc2ccccc2o1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.53
NPC1 O15118 8/20 0.50
ALDH1A1 P00352 7/20 0.50
RAB9A P51151 6/20 0.50
HSD17B10 Q99714 6/20 0.50
HPGD P15428 6/20 0.50
TP53 P04637 5/20 0.50
KDM4E B2RXH2 5/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
MAPT P10636 4/20 0.50
SMN1; SMN2 Q16637 4/20 0.50
PKM P14618 3/20 0.50
HCRTR1 O43613 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
ATM Q13315 1/20 0.49
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27713231 0.98 ALOX5 (0.51) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL824375 0.80 NPC1 (0.69) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL29531707 0.80 NPC1 (0.69) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL712314 0.80 GAA (0.54) NPC1ALDH1A1RAB9AHSD17B10HPGD
SCHEMBL11376024 0.79 SMN1; SMN2 (0.48) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL8970064 0.79 NPC1 (0.54) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL547804 0.79 NPC1 (0.50) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL17562381 0.75 ALOX5 (0.67) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL15771045 0.75 PTGS2 (0.49) ALOX5NPC1ALDH1A1RAB9AHSD17B10
SCHEMBL29117990 0.75 NPC1 (0.46) ALOX5NPC1ALDH1A1RAB9AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116925090-A Spiro compound and application thereof in organic light-emitting device and panel 上海天马微电子有限公司 2023-10-24 CN claimed
CN-113999220-A Compound containing benzophenanthrene furan structure and organic electroluminescent device 南京高光半导体材料有限公司 2022-02-01 CN claimed
CN-106103497-B Curable composition, optical component, and compound 富士胶片株式会社 2017-09-05 CN claimed
US-9112159-B2 Bipolar hosts for light emitting devices NITTO DENKO CORPORATION (JP) 2015-08-18 US claimed
WO-2014093361-A1 BIPOLAR HOSTS FOR LIGHT EMITTING DEVICES NITTO DENKO CORPORATION (JP) 2014-06-19 WO claimed
US-20140163237-A1 BIPOLAR HOSTS FOR LIGHT EMITTING DEVICES Nitto Denko Corportion (JP) 2014-06-12 US claimed
US-20080187978-A1 Anti-inflammatory medicaments FLYNN DANIEL L 2008-08-07 US claimed
US-20080064688-A1 Anti-inflammatory medicaments DECIPHERA PHARMACEUTICALS, LLC 2008-03-13 US claimed
EP-1585734-A4 ANTI-INFLAMMATORY MEDICAMENTS DECIPHERA PHARMACEUTICALS LLC (US) 2007-09-19 EP claimed
EP-1590344-A4 ANTI-CANCER MEDICAMENTS DECIPHERA PHARMACEUTICALS LLC (US) 2007-08-29 EP claimed
WO-2006014290-A2 ANTI-INFLAMMATORY MEDICAMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2006-02-09 WO claimed
US-20050288286-A1 Anti-inflammatory medicaments DECIPHERA PHARMACEUTICALS, LLC 2005-12-29 US claimed
EP-1590344-A2 ANTI-CANCER MEDICAMENTS Deciphera Pharmaceuticals, Inc. (US) 2005-11-02 EP claimed
EP-1585734-A2 ANTI-INFLAMMATORY MEDICAMENTS Deciphera Pharmaceuticals, LLC (US) 2005-10-19 EP claimed
US-20040180906-A1 Anti-inflammatory medicaments DECIPHERA PHARMACEUTICALS, LLC 2004-09-16 US claimed
US-20040176395-A1 Anti-cancer medicaments DECIPHERA PHARMACEUTICALS, LLC 2004-09-09 US claimed
WO-2004060305-A2 ANTI-CANCER MEDICAMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2004-07-22 WO claimed
WO-2004060306-A2 ANTI-INFLAMMATORY MEDICAMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2004-07-22 WO claimed
US-4578469-A COUMARIN DYES HOECHST AKTIENGESELLSCHAFT (DE) 1986-03-25 US claimed
US-4208513-A Benzoxazolyl-phenylstilbenes, processes for producing them, and their use as optical brighteners CIBA-GEIGY CORPORATION (US) 1980-06-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080064688-A1 Anti-inflammatory medicaments MIF, PTGES2, TNF ALOX5 514/4885NPC1 4549/4885ALDH1A1 3257/4885
US-20050288286-A1 Anti-inflammatory medicaments MIF, PTGES2, TNF ALOX5 514/4885NPC1 4549/4885ALDH1A1 3257/4885
US-20040180906-A1 Anti-inflammatory medicaments MIF, PTGES2, TNF ALOX5 514/4885NPC1 4549/4885ALDH1A1 3257/4885
US-20040176395-A1 Anti-cancer medicaments ABL1, ABL2, SRC ALOX5 3368/4885NPC1 4548/4885ALDH1A1 1475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.