Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GCGR | P47871 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081383 | 0.85 | BRAF (0.46) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL33656 | 0.81 | GAA (0.43) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL33678 | 0.81 | KDM4E (0.50) | BRAFPOLBTP53MAPTALDH1A1 | |
| SCHEMBL11280088 | 0.80 | KDM4E (0.58) | BRAFPOLBALDH1A1HPGDCYP1A2 | |
| SCHEMBL29000682 | 0.80 | MAPK14 (0.47) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| Ammonia Solution, Strong SCHEMBL25300630 | 0.80 | GAA (0.42) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL28104155 | 0.80 | KDM4E (0.49) | BRAFPOLBTP53MAPTALDH1A1 | |
| SCHEMBL649956 | 0.80 | HPGD (0.45) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9339022 | 0.77 | SMPD3 (0.46) | BRAFPOLBGCGRTP53MAPT | |
| SCHEMBL468691 | 0.77 | LTB4R (0.47) | BRAFALDH1A1HPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |