Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601744 | 0.78 | CES2 (0.52) | PDE2AIDO1CES2MPL | |
| SCHEMBL29827588 | 0.77 | PDE2A (0.50) | PDE2AIDO1CES2MPLPTPN5 | |
| SCHEMBL2147584 | 0.77 | PDE2A (0.50) | PDE2AIDO1CES2MPLPTPN5 | |
| SCHEMBL8781830 | 0.76 | CES2 (0.50) | PDE2ACES2PTPN5TSHRMAPK1 | |
| Lithium SCHEMBL2459422 | 0.75 | PDE2A (0.48) | PDE2AIDO1CES2MPLPTPN5 | |
| SCHEMBL2459420 | 0.75 | PDE2A (0.48) | PDE2AIDO1CES2MPLPTPN5 | |
| SCHEMBL11101764 | 0.74 | PDE2A (0.48) | PDE2ACES2PTPN5TSHRDAO | |
| SCHEMBL5841906 | 0.73 | CES2 (0.57) | PDE2ACES2PTPN5TSHRMAPK1 | |
| SCHEMBL27937088 | 0.73 | PDE2A (0.47) | PDE2AIDO1CES2MPLPTPN5 | |
| SCHEMBL6743200 | 0.73 | PDE2A (0.47) | PDE2AIDO1CES2MPLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330233-A1 | METHOD OF TREATING STROKE | ELI LILLY AND COMPANY (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002032389-A1 | METHOD OF TREATING STROKE | ELI LILLY AND COMPANY (US) | 2002-04-25 | — | — | WO | disclosed |