Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8118302 | 0.92 | HTR1A (0.52) | HTR1AHTR7HTR6CNR2OPRM1 | |
| SCHEMBL7138181 | 0.83 | HPGDS (0.49) | BACE1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7141176 | 0.82 | CYP1A2 (0.46) | BACE1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7143626 | 0.80 | BACE1 (0.45) | BACE1CNR2CNR1HPGDS | |
| SCHEMBL7179734 | 0.78 | BACE1 (0.47) | BACE1CNR2CNR1HPGDS | |
| SCHEMBL7140173 | 0.77 | BACE1 (0.43) | HTR1ABACE1CNR2CNR1HPGDS | |
| SCHEMBL8110914 | 0.77 | CYP1A2 (0.44) | BACE1SMN1; SMN2CNR2CYP1A2CYP2D6 | |
| SCHEMBL7138024 | 0.77 | SSTR3 (0.47) | BACE1SMN1; SMN2HPGDS | |
| SCHEMBL7135108 | 0.77 | CYP1A2 (0.46) | BACE1SMN1; SMN2CNR2CYP1A2CYP2D6 | |
| SCHEMBL7143478 | 0.76 | KCNH2 (0.49) | BACE1CNR2CYP2D6CNR1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | claimed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |