Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138024 | 0.92 | SSTR3 (0.47) | SSTR3BACE1HPGDSNPY5RROCK1 | |
| SCHEMBL7138181 | 0.92 | HPGDS (0.49) | CYP1A2CYP2D6CYP2C19CYP3A4BACE1 | |
| SCHEMBL8118487 | 0.91 | CYP1A2 (0.41) | CYP1A2CYP2D6CYP2C19CYP3A4SSTR3 | |
| SCHEMBL7143626 | 0.86 | BACE1 (0.45) | BACE1HPGDSNPY5RSCN2A | |
| SCHEMBL7179734 | 0.84 | BACE1 (0.47) | BACE1HPGDSNPY5RSCN2A | |
| SCHEMBL8110914 | 0.83 | CYP1A2 (0.44) | CYP1A2CYP2D6CYP2C19BACE1HPGDS | |
| SCHEMBL7140173 | 0.83 | BACE1 (0.43) | BACE1HPGDSNPY5RSCN2A | |
| SCHEMBL7135108 | 0.82 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C19BACE1HPGDS | |
| SCHEMBL7140310 | 0.82 | HTR1A (0.44) | CYP1A2CYP2D6CYP2C19CYP3A4BACE1 | |
| SCHEMBL7187293 | 0.81 | BACE1 (0.44) | SSTR3BACE1HPGDSNPY5RSCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |