Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735491 | 0.88 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL19007858 | 0.88 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL21319327 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL13880234 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL7472092 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL28747000 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL4890742 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL3741541 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL8989009 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL10047602 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |