Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577902 | 0.86 | ACHE (0.75) | MAPTMEN1KMT2AACHEHSD17B10 | |
| SCHEMBL2421879 | 0.84 | SMN1; SMN2 (0.65) | MAPTMEN1KMT2ATSHRACHE | |
| SCHEMBL3328543 | 0.84 | MAPT (0.79) | MAPTMEN1KMT2AACHEHSD17B10 | |
| SCHEMBL4163474 | 0.84 | MAPT (0.79) | MAPTMEN1KMT2AACHEHSD17B10 | |
| Fluoride SCHEMBL29135589 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AACHEHSD17B10 | |
| SCHEMBL8934649 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AACHEHSD17B10 | |
| SCHEMBL8934655 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2AACHEHSD17B10 | |
| SCHEMBL11472633 | 0.80 | ALDH1A1 (0.63) | MAPTMEN1KMT2ATSHRACHE | |
| SCHEMBL811086 | 0.79 | TSHR (0.49) | MAPTMEN1KMT2ATSHRACHE | |
| SCHEMBL6937549 | 0.79 | MEN1 (0.63) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |