Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096492 | 0.84 | CHRNB2 (0.44) | CHRNB2CHRNA4ADRA2AADRA2BADRA2C | |
| SCHEMBL6352342 | 0.82 | LMNA (0.44) | CHRNB2CHRNA4ALDH1A1POLBKMT2A | |
| SCHEMBL7098715 | 0.82 | LMNA (0.44) | CHRNB2CHRNA4ALDH1A1POLBKMT2A | |
| SCHEMBL2478525 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL644787 | 0.77 | POLB (0.49) | ALDH1A1POLBKMT2ACYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6017637 | 0.77 | ADRB2 (0.35) | CHRNB2CHRNA4ROCK1ALDH1A1POLB | |
| SCHEMBL1758868 | 0.73 | POLB (0.66) | MKNK1MKNK2POLBCYP1A2CYP2D6 | |
| SCHEMBL30791537 | 0.73 | POLB (0.66) | MKNK1MKNK2POLBCYP1A2CYP2D6 | |
| SCHEMBL28211335 | 0.73 | RYR2 (0.50) | CHRNB2CHRNA4ADRA2AADRA2BROCK1 | |
| SCHEMBL27915904 | 0.72 | RPS6KA3 (0.39) | CHRNB2CHRNA4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289982-A1 | BIOISOSTERIC BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 SECRETION INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096327-A1 | BIOISOSTERIC BENZAMIDE DERIVATIVES AND THEIR USE AS APoB-100 SECRETION INHIBITORS | GLAXO GROUP LIMITED (GB) | 2001-12-20 | — | — | WO | disclosed |