Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.34 |
| ▸ | RARB | P10826 | 6/20 | 0.34 |
| ▸ | RARG | P13631 | 6/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142829 | 0.86 | BACE1 (0.31) | RARARARBRARG | |
| SCHEMBL7140448 | 0.85 | RARA (0.36) | RARARARBRARGACACBCYP26A1 | |
| SCHEMBL7139418 | 0.83 | RARB (0.49) | RARARARBRARGACACBCYP26A1 | |
| SCHEMBL7137830 | 0.79 | RARA (0.38) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL7143699 | 0.77 | SMN1; SMN2 (0.42) | RARARARBRARGKMT2AAKR1B1 | |
| SCHEMBL7139314 | 0.75 | RARB (0.52) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7143104 | 0.74 | RARB (0.48) | RARARARBRARGACACBCYP26A1 | |
| SCHEMBL9817786 | 0.72 | CYP26A1 (0.45) | RARARARBRARGACACBCYP26A1 | |
| SCHEMBL7652468 | 0.72 | MAP3K14 (0.33) | CYP26A1CYP26B1 | |
| SCHEMBL4373679 | 0.71 | APP (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |