Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142341 | 0.95 | LTA4H (0.77) | LTA4HL3MBTL1ALDH1A1KDM4EATM | |
| SCHEMBL8909943 | 0.89 | ALDH1A1 (0.66) | L3MBTL1ALDH1A1KDM4EATMSIGMAR1 | |
| SCHEMBL8909936 | 0.89 | ALDH1A1 (0.66) | L3MBTL1ALDH1A1KDM4EATMSIGMAR1 | |
| SCHEMBL491545 | 0.88 | SIGMAR1 (0.67) | L3MBTL1ALDH1A1KDM4EATMSIGMAR1 | |
| SCHEMBL8910535 | 0.86 | ALDH1A1 (0.69) | LTA4HL3MBTL1ALDH1A1KDM4EATM | |
| SCHEMBL8693251 | 0.86 | ALDH1A1 (0.69) | LTA4HL3MBTL1ALDH1A1KDM4EATM | |
| SCHEMBL7135531 | 0.85 | LTA4H (0.78) | LTA4HALDH1A1KDM4EHRH3SMN1; SMN2 | |
| Oxalic Acid SCHEMBL8694605 | 0.84 | ALDH1A1 (0.66) | LTA4HL3MBTL1ALDH1A1KDM4EATM | |
| SCHEMBL5281462 | 0.84 | SIGMAR1 (0.63) | LTA4HL3MBTL1ALDH1A1KDM4EHRH3 | |
| SCHEMBL8871799 | 0.82 | KDM4E (0.64) | L3MBTL1ALDH1A1KDM4EATMHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506876-B1 | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. | 2003-01-14 | — | — | US | disclosed |
| EP-0804427-B1 | LTA4 HYDROLASE INHIBITORS | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1221441-A2 | LTA4 Hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-0786992-A2 | LTA 4? HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5585492-A | USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES WHICH ARE MEDIATED BY LTB4 PRODUCTION, SUCH AS PSORIASIS, ULCERATIVE COLITIS, IRRITABLE BOWEL DISEASE AND ASTHMA | G. D. SEARLE & CO. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996010999-A2 | LTA4 HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |