Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141657 | 0.81 | HDAC4 (0.34) | ADORA3GBA1PTPN11 | |
| SCHEMBL7141642 | 0.81 | STK17B (0.39) | ADORA3CA12CA1CA2CA9 | |
| Methylamine SCHEMBL6776180 | 0.72 | ATM (0.45) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL29347082 | 0.71 | ADORA3 (0.48) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL21741859 | 0.71 | PTPN11 (0.40) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL18041425 | 0.69 | BRD4 (0.42) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL24290975 | 0.68 | FPR3 (0.51) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL13598892 | 0.68 | PTPN11 (0.50) | ADORA3CA12CA1CA2CA9 | |
| SCHEMBL19891578 | 0.68 | PTPN11 (0.51) | CA12CA1CA2CA9GBA1 | |
| SCHEMBL236269 | 0.67 | TDP1 (0.48) | ADORA3CA1CA2CYP3A4PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272185-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001066099-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |