Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409382 | 0.86 | NPY5R (0.45) | NPY5RMMEACEECE1SLC6A9 | |
| SCHEMBL5413603 | 0.76 | KAT6A (0.41) | NPY5RMMEACEECE1SLC6A9 | |
| SCHEMBL5413600 | 0.74 | ECE1 (0.56) | NPY5RMMEACEECE1SLC6A9 | |
| SCHEMBL5413596 | 0.74 | ECE1 (0.56) | NPY5RMMEACEECE1SLC6A9 | |
| SCHEMBL5413360 | 0.68 | LMNA (0.45) | ECE1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL7145132 | 0.65 | L3MBTL1 (0.37) | MMEACEECE1SLC6A9LMNA | |
| SCHEMBL5409515 | 0.65 | L3MBTL1 (0.37) | MMEACEECE1SLC6A9LMNA | |
| SCHEMBL10332417 | 0.65 | ALDH1A1 (0.50) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5409511 | 0.63 | ECE1 (0.50) | MMEACEECE1SLC6A9ALDH1A1 | |
| SCHEMBL5409505 | 0.63 | ECE1 (0.50) | MMEACEECE1SLC6A9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |