Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | ADK | P55263 | 1/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001368 | 0.80 | NISCH (0.52) | NISCHMTORADKCSNK1A1TYRO3 | |
| Hydrochloric Acid SCHEMBL29265356 | 0.78 | NISCH (0.50) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL18396006 | 0.77 | NISCH (0.63) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL9719773 | 0.77 | NISCH (1.00) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL8901 | 0.77 | NISCH (1.00) | NISCHMTORADKCSNK1A1TYRO3 | |
| SCHEMBL3053174 | 0.77 | ADRA2A (0.46) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL5796856 | 0.75 | NISCH (0.95) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL8898735 | 0.75 | NISCH (0.95) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL1954238 | 0.75 | NISCH (0.95) | NISCHMTORADKCSNK1A1TYRO3 | |
| 2-Phenylimidazole SCHEMBL11072040 | 0.75 | NISCH (0.95) | NISCHMTORADKCSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0996443-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999001128-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |
| US-5560785-A | TREATING SURFACE WITH SOLUTION OF IMIDAZOLE COMPOUND, COPPER COMPOUND, ZINC COMPOUND, STABILIZERS | SHIKOKU CHEMICALS CORPORATION (JP) | 1996-10-01 | — | — | US | disclosed |
| US-5498301-A | ON A PRINTED WIRING BOARD, HEAT RESISTANT, MOISTURE RESISTANT, A 2-ARYLIMIDAZOLE, CARBOXYLIC ACID, AMMONIA, WATER | SHIKOKU CHEMICALS CORPORATION (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0627499-A1 | Agent for treating surfaces of copper and copper alloys | SHIKOKU CHEMICALS CORPORATION (JP) | 1994-12-07 | — | — | EP | disclosed |