Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.67 |
| ▸ | THRA | P10827 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | PPARG | P37231 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | USP2 | O75604 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | TTR | P02766 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.67 |
| ▸ | RXRA | P19793 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139433 | 1.00 | THRB (0.67) | THRBTHRAMEN1KMT2APPARG | |
| SCHEMBL7142110 | 1.00 | THRB (0.67) | THRBTHRAMEN1KMT2APPARG | |
| SCHEMBL6041028 | 0.87 | SIRT5 (0.50) | THRBTHRAMEN1KMT2APPARG | |
| SCHEMBL6041026 | 0.87 | SIRT5 (0.50) | THRBTHRAMEN1KMT2APPARG | |
| SCHEMBL13662871 | 0.82 | THRB (0.70) | THRBTHRAMEN1KMT2APPARG | |
| SCHEMBL20016234 | 0.82 | THRB (0.70) | THRBTHRAMEN1KMT2APPARG | |
| Levothyroxine SCHEMBL1997042 | 0.82 | THRB (0.97) | THRBTHRAMEN1KMT2APPARG | |
| Thyroxine SCHEMBL2014581 | 0.82 | THRB (0.97) | THRBTHRAMEN1KMT2APPARG | |
| Levothyroxine SCHEMBL1995241 | 0.82 | THRB (0.97) | THRBTHRAMEN1KMT2APPARG | |
| Dextrothyroxine SCHEMBL1477972 | 0.82 | THRB (0.97) | THRBTHRAMEN1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030186847-A1 | Insulin derivatives and synthesis thereof | BTG INTERNATIONAL LIMITED (GB) | 2003-10-02 | — | — | US | disclosed |
| EP-1299418-A1 | INSULIN DERIVATIVES AND SYNTHESIS THEREOF | BTG INTERNATIONAL LIMITED (Company No. 2664412) (GB) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004515-A1 | INSULIN DERIVATIVES AND SYNTHESIS THEREOF | BTG INTERNATIONAL LIMITED (GB) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186847-A1 | Insulin derivatives and synthesis thereof | THRB, IRS1, IGFBP1 | THRB 1/4885THRA 10/4885MEN1 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.