Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5410369 | 0.77 | ECE1 (0.43) | ECE1OPRK1 | |
| SCHEMBL5422520 | 0.74 | TBXAS1 (0.43) | ECE1TBXAS1CYP19A1LMNA | |
| SCHEMBL9216047 | 0.74 | TBXAS1 (0.37) | TBXAS1CYP19A1 | |
| SCHEMBL5412971 | 0.74 | ECE1 (0.43) | ECE1GBA2LMNAOPRD1OPRK1 | |
| SCHEMBL9369510 | 0.73 | SIGMAR1 (0.32) | ECE1CYP19A1 | |
| SCHEMBL9428575 | 0.72 | ECE1 (0.44) | ECE1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5407269 | 0.67 | ECE1 (0.52) | ECE1CYP3A4LMNAOPRD1OPRK1 | |
| SCHEMBL31629521 | 0.66 | SMN1; SMN2 (0.54) | ECE1GBA2LMNAOPRD1OPRK1 | |
| SCHEMBL5401467 | 0.66 | ECE1 (0.43) | ECE1CYP2D6GBA2LMNA | |
| SCHEMBL7142974 | 0.65 | ECE1 (0.50) | ECE1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |