Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.64 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.64 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.64 |
| ▸ | GABRD | O14764 | 1/20 | 0.64 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | GABRE | P78334 | 1/20 | 0.64 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.64 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.64 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL10707046 | 0.90 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL4046179 | 0.90 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9669357 | 0.89 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7276188 | 0.88 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7362085 | 0.87 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8871585 | 0.87 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11087842 | 0.86 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11113143 | 0.86 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7332213 | 0.86 | GABRG2 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7274213 | 0.86 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059389-B1 | IMIDAZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-12-12 | — | — | EP | claimed |
| EP-1202977-B1 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-12-17 | — | — | EP | disclosed |
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0451626-B1 | The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids | NEUROSEARCH AS (DK) | 1997-09-10 | — | — | EP | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0672666-A2 | Imidazodiazepins | F. Hoffmann-La Roche AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| EP-0150040-B1 | Imidazodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-08-31 | — | — | EP | disclosed |
| US-5270306-A | Method of antagonizing excitatory amino acids by administration of imidazobenzodiazepine compounds | NEUROSEARCH A/S (DK) | 1993-12-14 | — | — | US | disclosed |
| EP-0451626-A2 | The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids | NEUROSEARCH A/S (DK) | 1991-10-16 | — | — | EP | disclosed |
| US-4775671-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
| US-4352817-A | ANTIDOTE FOR TRANQUILLIZING EFFECTS OF 1,4-BENZODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| US-4352818-A | ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0059390-A1 | Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |