Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.60 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.60 |
| ▸ | GABRP | O00591 | 1/20 | 0.60 |
| ▸ | GABRD | O14764 | 1/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | GABRE | P78334 | 1/20 | 0.60 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.60 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.60 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046179 | 0.91 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7135694 | 0.88 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7142433 | 0.87 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8871585 | 0.86 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9669357 | 0.85 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10962588 | 0.83 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Sarmazenil SCHEMBL195304 | 0.82 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11108814 | 0.82 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7362705 | 0.81 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9869426 | 0.81 | GABRG2 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790999-A1 | OXAZOLYL- AND THIAZOLYLIMIDAZO-BENZO- AND THIENODIAZEPINES AND THEIR USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015129-A1 | OXAZOLYL- AND THIAZOLYLIMIDAZO-BENZO- AND THIENODIAZEPINES AND THEIR USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-23 | — | — | WO | disclosed |