Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865022 | 0.84 | ALDH1A1 (0.44) | CYP3A4SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL220662 | 0.79 | CYP19A1 (0.50) | CYP3A4SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL21645386 | 0.79 | HTT (0.42) | SMN1; SMN2LMNAALDH1A1KMT2AGAA | |
| SCHEMBL7137054 | 0.78 | HTR6 (0.49) | SMN1; SMN2LMNAALDH1A1TSHRKMT2A | |
| SCHEMBL7142939 | 0.78 | MAPT (0.48) | CYP3A4SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL23113448 | 0.78 | MEN1 (0.42) | CYP3A4SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL31746020 | 0.75 | NR3C2 (0.37) | SMN1; SMN2LMNAALDH1A1KMT2AGAA | |
| Ammonia Solution, Strong SCHEMBL28007719 | 0.75 | CYP19A1 (0.46) | CYP3A4SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL5864975 | 0.71 | TSHR (0.48) | CYP3A4LMNAALDH1A1TSHRKMT2A | |
| SCHEMBL29664408 | 0.71 | TSHR (0.48) | CYP3A4LMNAALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | disclosed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |