Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11736266 | 0.87 | ALOX15 (0.52) | ALDH1A1IGFBP3CA1CA2TDP1 | |
| SCHEMBL7142876 | 0.84 | CYP3A4 (0.50) | ALDH1A1TSHRCYP3A4SMN1; SMN2CYP19A1 | |
| SCHEMBL220662 | 0.80 | CYP19A1 (0.50) | ALDH1A1TDP1ALOX15TSHRHIF1A | |
| SCHEMBL21645386 | 0.80 | HTT (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL23113448 | 0.79 | MEN1 (0.42) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL1797796 | 0.79 | ALDH1A1 (0.49) | ALDH1A1IGFBP3CA1CA2TDP1 | |
| SCHEMBL30380635 | 0.79 | ALDH1A1 (0.44) | ALDH1A1IGFBP3CA1CA2TDP1 | |
| SCHEMBL18839539 | 0.79 | ALDH1A1 (0.44) | ALDH1A1IGFBP3CA1CA2TDP1 | |
| SCHEMBL31746020 | 0.77 | NR3C2 (0.37) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| Ammonia Solution, Strong SCHEMBL28007719 | 0.77 | CYP19A1 (0.46) | ALDH1A1TDP1ALOX15TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12509451-B2 | Heteroaryl amide inhibitors of CD38 | NAPA THERAPEUTICS LIMITED (IM) | 2025-12-30 | — | — | US | disclosed |
| US-20250382292-A1 | COMPOUNDS FOR TREATING LIGHT CHAIN AMYLOIDOSIS | PROTEGO BIOPHARMA INC (US) | 2025-12-18 | — | — | US | disclosed |
| US-20230382901-A1 | HETEROARYL AMIDE INHIBITORS OF CD38 | NAPA THERAPEUTICS LIMITED (GB) | 2023-11-30 | — | — | US | disclosed |
| US-20230382901-A1 | HETEROARYL AMIDE INHIBITORS OF CD38 | NAPA THERAPEUTICS LIMITED (GB) | 2023-11-30 | — | — | US | disclosed |
| CN-116710090-A | Heteroaryl amide inhibitors of CD38 | NAPA医疗有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4225310-A1 | HETEROARYL AMIDE INHIBITORS OF CD38 | Napa Therapeutics Ltd. (VG) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022077034-A1 | HETEROARYL AMIDE INHIBITORS OF CD38 | NAPA THERAPEUTICS LTD. (VG) | 2022-04-14 | — | — | WO | disclosed |
| WO-2019241787-A9 | NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2020-02-06 | — | — | WO | disclosed |
| CN-100516061-C | Pyridine derivatives as NMDA receptor ligands | HOFFMANN LA ROCHE (CH) | 2009-07-22 | — | — | CN | disclosed |
| CN-1837195-A | Pyridine derivatives as nmda-receptor subtype blockers | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | CN | disclosed |
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | disclosed |
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | ALANINE ALEXANDER (FR) | 2004-04-08 | — | — | US | disclosed |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | HOFFMANN-LA ROCHE INC. | 2003-07-31 | — | — | US | disclosed |
| US-20030119870-A1 | Pyridine substituted isoquinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | US | disclosed |
| WO-2003040128-A1 | PYRIDINE DERIVATIVES AS NMDA RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-15 | — | — | WO | disclosed |
| WO-2003037333-A1 | PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | ALDH1A1 832/4885IGFBP3 4357/4885CA1 1497/4885 |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | ALDH1A1 832/4885IGFBP3 4357/4885CA1 1497/4885 |
| US-20230382901-A1 | HETEROARYL AMIDE INHIBITORS OF CD38 | CD38, CD22, PARP12 | ALDH1A1 386/4885IGFBP3 4435/4885CA1 2559/4885 |
| US-20030119870-A1 | Pyridine substituted isoquinoline derivatives | GRIN1, GRIN2C, GRIN2A | ALDH1A1 1287/4885IGFBP3 3781/4885CA1 1690/4885 |
| US-12509451-B2 | Heteroaryl amide inhibitors of CD38 | CD38, FCGRT, BCL6 | ALDH1A1 215/4885IGFBP3 2067/4885CA1 501/4885 |
| US-20250382292-A1 | COMPOUNDS FOR TREATING LIGHT CHAIN AMYLOIDOSIS | TTR, CRYAA, BCL6 | ALDH1A1 925/4885IGFBP3 4008/4885CA1 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.