Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142947 | 0.87 | LSS (0.39) | LSSGAAMGLLTRPA1FAAH | |
| SCHEMBL6447603 | 0.87 | LSS (0.55) | LSSGAAMGLLNPY2RTRPA1 | |
| SCHEMBL7139780 | 0.84 | MGLL (0.46) | LSSMGLL | |
| SCHEMBL7142436 | 0.84 | LSS (0.46) | LSSGAAMGLLNPY2R | |
| SCHEMBL6450336 | 0.82 | LSS (0.49) | LSSGAANPY2RFAAH | |
| SCHEMBL6450231 | 0.80 | LSS (0.50) | LSSNPY2RFAAH | |
| SCHEMBL6447566 | 0.80 | LSS (0.61) | LSSGAAMGLLNPY2RTRPA1 | |
| SCHEMBL6449189 | 0.78 | LSS (0.70) | LSSGAAMGLLNPY2RTRPA1 | |
| SCHEMBL2618043 | 0.77 | GAA (0.51) | GAAMGLLNPY2RTRPA1FAAH | |
| SCHEMBL7147952 | 0.77 | FAAH (0.41) | GAAMGLLNPY2RTRPA1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |