Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143701 | 0.86 | HTR6 (0.47) | KMT2AHTR6SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7136667 | 0.83 | KMT2A (0.48) | KMT2ASMN1; SMN2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL7140750 | 0.77 | KMT2A (0.38) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL7140746 | 0.77 | KMT2A (0.38) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL7143403 | 0.76 | HTR6 (0.49) | KMT2AHTR6MAPTALDH1A1GAA | |
| (Phenylsulfonyl)Benzene SCHEMBL28738232 | 0.74 | HTR6 (0.61) | KMT2AHTR6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7138321 | 0.72 | ALDH1A1 (0.42) | KMT2AALDH1A1ALOX15HSD17B10HDAC1 | |
| SCHEMBL7139891 | 0.71 | NPC1 (0.48) | KMT2AHTR6MAPTSMN1; SMN2ALDH1A1 | |
| (Phenylsulfonyl)Benzene SCHEMBL2381369 | 0.70 | HTR6 (0.74) | KMT2AHTR6MAPTSMN1; SMN2ALDH1A1 | |
| (Phenylsulfonyl)Benzene SCHEMBL29058880 | 0.70 | HTR6 (0.74) | KMT2AHTR6MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | disclosed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |