Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140750 | 1.00 | KMT2A (0.38) | KMT2AALDH1A1MEN1ALOX15HSD17B10 | |
| SCHEMBL7143397 | 0.77 | KMT2A (0.42) | KMT2AALDH1A1ALOX15HSD17B10HDAC1 | |
| SCHEMBL7138321 | 0.67 | ALDH1A1 (0.42) | KMT2AALDH1A1MEN1ALOX15HSD17B10 | |
| SCHEMBL19024362 | 0.66 | GLO1 (0.49) | KMT2AALDH1A1MEN1ALOX15HSD17B10 | |
| SCHEMBL19024363 | 0.66 | GLO1 (0.49) | KMT2AALDH1A1MEN1ALOX15HSD17B10 | |
| SCHEMBL7143403 | 0.65 | HTR6 (0.49) | KMT2AALDH1A1MEN1HPGDMAPT | |
| SCHEMBL2378380 | 0.64 | MTNR1A (0.48) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL7143701 | 0.64 | HTR6 (0.47) | KMT2AALDH1A1MEN1CYP2C19LMNA | |
| SCHEMBL16118567 | 0.64 | MAPT (0.53) | KMT2AALDH1A1MEN1HPGDMAPT | |
| SCHEMBL989828 | 0.64 | ALDH1A1 (0.66) | KMT2AALDH1A1MEN1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |