Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | GALR3 | O60755 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 8/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386452 | 0.80 | NR2F2 (0.64) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL1863835 | 0.77 | POLB (0.57) | RAB9ASMN1; SMN2LMNAMAPK1HIF1A | |
| SCHEMBL15347754 | 0.77 | LMNA (0.65) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL29386010 | 0.76 | EGFR (1.00) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL7612718 | 0.76 | EGFR (1.00) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL712360 | 0.76 | KMT2A (0.58) | EGFRSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL20120009 | 0.75 | AURKA (0.46) | SMN1; SMN2HTTLMNAMAPK1TSHR | |
| Hydrochloric Acid SCHEMBL8178476 | 0.75 | LMNA (1.00) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL13283188 | 0.74 | L3MBTL1 (0.65) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 | |
| SCHEMBL9430904 | 0.74 | EGFR (0.68) | EGFRNR2F2RAB9AGALR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609672-B2 | Piperazinylpyrimidine analogues as protein kinase inhibitors | UNIVERSITY OF THE PACIFIC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | DCK, PAK5, CDK2 | EGFR 928/4885NR2F2 2703/4885RAB9A 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.