Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416718 | 1.00 | LMNA (0.37) | LMNATSHRRBP4HSPA1APTPN7 | |
| SCHEMBL5416715 | 1.00 | LMNA (0.37) | LMNATSHRRBP4HSPA1APTPN7 | |
| SCHEMBL5316457 | 0.89 | BCHE (0.39) | LMNATSHRRBP4HSPA1APTPN7 | |
| SCHEMBL6217421 | 0.81 | MEN1 (0.40) | LMNAHSPA1APTPN7TDP1MEN1 | |
| SCHEMBL5133257 | 0.81 | GPR119 (0.47) | — | |
| SCHEMBL28982266 | 0.79 | BACE1 (0.39) | LMNATSHRRBP4BACE1ALDH1A1 | |
| SCHEMBL21707918 | 0.79 | BACE1 (0.39) | LMNATSHRRBP4BACE1ALDH1A1 | |
| SCHEMBL3313723 | 0.79 | BACE1 (0.39) | LMNATSHRRBP4BACE1ALDH1A1 | |
| SCHEMBL14276928 | 0.76 | ALDH1A1 (0.41) | ACHEALDH1A1BCHEADRA2AADRA2B | |
| SCHEMBL21871876 | 0.76 | LMNA (0.37) | LMNATSHRACHEBCHEPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902684-B1 | HEXAHYDRO-PYRIDO(4,3-B)INDOLE DERIVATIVES AS ANTIPSYCHOTIC DRUGS | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6057325-A | HAVE CENTRAL DOPAMINE AND SEROTONIN ANTOGONISTIC ACTIVITY | JANSSEN PHARMACEUTIA, N.V. (BE) | 2000-05-02 | — | — | US | disclosed |