Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.56 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139532 | 0.86 | HTR6 (0.57) | HTR6EDNRAEDNRBCA1CA2 | |
| SCHEMBL7139519 | 0.80 | HTR6 (0.74) | HTR6 | |
| SCHEMBL27492911 | 0.75 | HTR6 (0.44) | HTR6F2 | |
| SCHEMBL27470885 | 0.74 | HTR6 (0.43) | HTR6 | |
| SCHEMBL27470884 | 0.74 | HTR6 (0.43) | HTR6 | |
| SCHEMBL7138620 | 0.72 | HTR6 (1.00) | HTR6 | |
| SCHEMBL7142065 | 0.72 | HTR6 (0.57) | HTR6CA1CA2AKR1B1 | |
| SCHEMBL3249669 | 0.69 | HTR6 (0.73) | HTR6CA1CA2CA9AKR1B1 | |
| SCHEMBL7138338 | 0.69 | HTR6 (0.48) | HTR6CA1CA2CA9AKR1B1 | |
| SCHEMBL547461 | 0.69 | CA1 (0.68) | HTR6CA1CA2CA9AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |