Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139241 | 0.83 | MMP1 (0.57) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7141116 | 0.77 | MMP1 (0.51) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7134744 | 0.77 | MMP2 (0.49) | MMP3ADAM17MMP1ACACBMMP13 | |
| SCHEMBL7136841 | 0.76 | MMP1 (0.50) | MMP3MMP1MMP13MMP2MMP9 | |
| SCHEMBL7140995 | 0.74 | MMP1 (0.61) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7135520 | 0.72 | MMP1 (0.49) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7140315 | 0.72 | MMP1 (0.49) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7143794 | 0.71 | MMP1 (0.73) | MMP3MMP1MMP13MMP2MMP9 | |
| SCHEMBL7330071 | 0.70 | MMP1 (0.59) | MMP3ADAM17MMP1MMP13MMP2 | |
| SCHEMBL7141637 | 0.69 | MMP1 (0.54) | MMP3ADAM17MMP1MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041072-B1 | Dioxocyclopentyl hydroxamic acids | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6214870-B1 | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS | PFIZER INC | 2001-04-10 | — | — | US | disclosed |
| EP-1041072-A1 | Dioxocyclopentyl hydroxamic acids | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |