Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 9/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143794 | 0.84 | MMP1 (0.73) | MMP1MMP13MMP8MMP12MMP2 | |
| SCHEMBL7140995 | 0.83 | MMP1 (0.61) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL7139241 | 0.82 | MMP1 (0.57) | MMP1MMP13MMP8MMP12MMP2 | |
| SCHEMBL7137273 | 0.77 | MMP1 (0.55) | MMP1MMP13MMP8MMP12MMP7 | |
| SCHEMBL7141637 | 0.76 | MMP1 (0.54) | MMP1MMP13MMP8MMP12MMP7 | |
| SCHEMBL7144004 | 0.76 | MMP3 (0.42) | MMP1MMP13MMP8MMP12MMP7 | |
| SCHEMBL7134771 | 0.76 | MMP1 (0.53) | MMP1MMP13MMP8MMP12MMP7 | |
| SCHEMBL7140254 | 0.75 | MMP1 (0.43) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL7137871 | 0.75 | MMP1 (0.49) | MMP1HDAC3HDAC8HDAC6MMP13 | |
| SCHEMBL7330071 | 0.75 | MMP1 (0.59) | MMP1MMP13MMP8MMP7MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041072-B1 | Dioxocyclopentyl hydroxamic acids | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6214870-B1 | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS | PFIZER INC | 2001-04-10 | — | — | US | disclosed |
| EP-1041072-A1 | Dioxocyclopentyl hydroxamic acids | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |