SCHEMBL7144056

SCHEMBL7144056

O=Cc1ccccc1Cc1ccc2c(c1)OCO2

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.62
TDP1 Q9NUW8 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
MEN1 O00255 1/20 0.50
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
MAPT P10636 1/20 0.49
ALDH1A1 P00352 2/20 0.49
HSD17B10 Q99714 1/20 0.49
PKM P14618 1/20 0.48
TSHR P16473 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
POLB P06746 1/20 0.47
CMA1 P23946 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46
VKORC1 Q9BQB6 1/20 0.46
CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9391810 0.84 CYP1A2 (0.49) KMT2ATDP1L3MBTL1MEN1CYP1A2
SCHEMBL7651963 0.80 PTGER3 (0.66) KMT2AMEN1CYP1A2CYP3A4MAPT
SCHEMBL1422874 0.80 ALDH1A1 (0.58) CYP1A2CYP3A4MAPTALDH1A1TAAR1
SCHEMBL108109 0.79 TAAR1 (0.62) CYP1A2CYP3A4MAPTALDH1A1CMA1
SCHEMBL27419118 0.79 TDP1 (0.68) KMT2ATDP1L3MBTL1CYP1A2CYP3A4
SCHEMBL13851903 0.79 L3MBTL1 (0.55) KMT2ATDP1L3MBTL1MEN1CYP1A2
Hydrochloric Acid SCHEMBL4942544 0.78 ALDH1A1 (0.56) KMT2AMEN1CYP1A2CYP3A4MAPT
SCHEMBL6724285 0.78 CYP3A4 (0.51) KMT2ACYP1A2CYP3A4MAPTALDH1A1
SCHEMBL9672470 0.78 TAAR1 (0.53) KMT2ACYP1A2CYP3A4MAPTALDH1A1
SCHEMBL21154355 0.78 CALM1 (0.54) KMT2AMEN1CYP3A4MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012128582-A2 A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME HYUNDAI PHARM CO., LTD. (KR) 2012-09-27 WO disclosed
EP-0921116-B1 N-(4-carbamimido-phenyl)-glycine amide derivatives HOFFMANN LA ROCHE (CH) 2003-06-18 EP disclosed
US-6140353-A USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. (US) 2000-10-31 US disclosed
EP-0921116-A1 N-(4-carbamimido-phenyl)-glycine amide derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-06-09 EP disclosed