SCHEMBL7144094

SCHEMBL7144094

CC(=O)c1ccc(F)c(Cl)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.44
MAOA P21397 2/20 0.44
CES2 O00748 3/20 0.40
CES1 P23141 3/20 0.40
ALDH1A1 P00352 3/20 0.37
KMT2A Q03164 2/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KCNH2 Q12809 1/20 0.36
BRD4 O60885 1/20 0.35
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
MAPT P10636 1/20 0.35
TNF P01375 1/20 0.35
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL106184 0.83 MAOB (0.42) MAOBMAOACES2CES1ALDH1A1
SCHEMBL22114181 0.83 MAOB (0.42) MAOBMAOACES2CES1ALDH1A1
SCHEMBL1901357 0.83 MAOB (0.42) MAOBMAOACES2CES1ALDH1A1
SCHEMBL31146017 0.81 KMT2A (0.49) MAOBCES2CES1ALDH1A1KMT2A
SCHEMBL8242079 0.81 KMT2A (0.49) MAOBCES2CES1ALDH1A1KMT2A
SCHEMBL109128 0.80 TSHR (0.48) CES2CES1ALDH1A1SMN1; SMN2ALOX15
SCHEMBL110164 0.80 ALDH1A1 (0.50) MAOBCES2CES1ALDH1A1KMT2A
SCHEMBL3337749 0.79 MAOB (0.42) MAOBMAOACES2CES1ALDH1A1
SCHEMBL2584915 0.78 DGAT1 (0.47) CES2CES1ALDH1A1KMT2ALMNA
SCHEMBL7407091 0.78 ABL1 (0.51) CES2CES1ALDH1A1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1114821-B1 Benzopyrans and their use as therapeutic agents SMITHKLINE BEECHAM PLC (GB) 2003-09-17 EP disclosed
EP-0764157-B1 BENZOPYRANS AND THEIR USE AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM PLC (GB) 2002-01-02 EP disclosed
EP-1114821-A1 Benzopyrans and their use as therapeutic agents SMITHKLINE BEECHAM PLC (GB) 2001-07-11 EP disclosed
US-5760074-A Treatment SMITHKLINE BEECHAM P.L.C. (GB) 1998-06-02 US disclosed
EP-0764157-A1 BENZOPYRANS AND THEIR USE AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM PLC (GB) 1997-03-26 EP disclosed
WO-1995034545-A1 BENZOPYRANS AND THEIR USE AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM PLC (GB) 1995-12-21 WO disclosed