Sugi Predict

Sugi Predict / Compounds / SCHEMBL110164

SCHEMBL110164

SCHEMBL110164

O=C(Cl)c1ccc(F)c(Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ CES2 O00748 4/20 0.41
▸ CES1 P23141 4/20 0.41
▸ P2RX7 Q99572 5/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ CASP1 P29466 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ GAA P10253 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PIK3CA P42336 1/20 0.33
▸ DAO P14920 1/20 0.33
▸ TNF P01375 1/20 0.33
▸ MGAM O43451 1/20 0.33
▸ AMY1A P0DUB6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL103521 0.85 ALDH1A1 (0.44) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL1774412 0.84 ALDH1A1 (0.48) ALDH1A1ALOX15CES2CES1P2RX7
SCHEMBL9860898 0.84 CES2 (0.50) ALDH1A1ALOX15CES2CES1P2RX7
SCHEMBL109128 0.82 TSHR (0.48) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL106326 0.81 ALDH1A1 (0.45) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL109636 0.81 ALDH1A1 (0.45) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL785155 0.80 ALDH1A1 (0.65) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL2584915 0.80 DGAT1 (0.47) ALDH1A1CES2CES1TSHRCASP1
SCHEMBL7144094 0.80 MAOB (0.44) ALDH1A1ALOX15CES2CES1SMN1; SMN2
SCHEMBL27631068 0.78 ALDH1A1 (0.42) ALDH1A1ALOX15CES2CES1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12338243-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-06-24 — — US disclosed
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 — — US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20220235062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-28 — — US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 — — US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 — — US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 — — US disclosed
US-20120157436-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LIMITED (GB) 2012-06-21 — — US disclosed
US-20120157436-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LIMITED (GB) 2012-06-21 — — US disclosed
US-20120157436-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LIMITED (GB) 2012-06-21 — — US disclosed
EP-2424869-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS Glaxo Group Limited (GB) 2012-03-07 — — EP disclosed
WO-2010125102-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LIMITED (GB) 2010-11-04 — — WO disclosed
WO-2010125102-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LIMITED (GB) 2010-11-04 — — WO disclosed
CN-1777584-A As 5-HT1F(Piperidyloxy) phenyl, (peridyloxy) pyridyl, (peridylthio) phenyl and (peridylthio) pyridyl compounds of agonists LILLY CO ELI (US) 2006-05-24 — — CN disclosed
EP-1140735-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2001-10-10 — — EP disclosed
US-6187952-B1 Two-step production of 3-chloro-4-fluoro-benzoyl chloride by chlorination CLARIANT GMBH (DE) 2001-02-13 — — US disclosed
WO-2000040524-A1 PREPARATION OF NUCLEAR CHLORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 2000-07-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220235062-A1 P2X7 MODULATORS P2RX7, P2RX4, P2RX1 ALDH1A1 1107/4885ALOX15 989/4885CES2 2229/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 ALDH1A1 1628/4885ALOX15 1190/4885CES2 2281/4885
US-12338243-B2 P2X7 modulators P2RX7, P2RX4, P2RX1 ALDH1A1 1107/4885ALOX15 989/4885CES2 2229/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 ALDH1A1 1628/4885ALOX15 1190/4885CES2 2281/4885
US-20120157436-A1 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS P2RX7, P2RX6, P2RX3 ALDH1A1 2283/4885ALOX15 1993/4885CES2 3454/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 ALDH1A1 1628/4885ALOX15 1190/4885CES2 2281/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 ALDH1A1 1628/4885ALOX15 1190/4885CES2 2281/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 ALDH1A1 1628/4885ALOX15 1190/4885CES2 2281/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.