Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 18/20 | 0.50 |
| ▸ | RARG | P13631 | 18/20 | 0.50 |
| ▸ | RARA | P10276 | 15/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140394 | 0.91 | RARB (0.40) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7706434 | 0.90 | RARB (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140796 | 0.90 | RARB (0.48) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7137833 | 0.88 | RARB (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7139314 | 0.85 | RARB (0.52) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140836 | 0.83 | RARA (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140832 | 0.83 | RARA (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7139191 | 0.81 | — | — | |
| SCHEMBL7139476 | 0.80 | MAP3K14 (0.30) | — | |
| SCHEMBL7136046 | 0.79 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331988-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017027280-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2017-02-16 | — | — | WO | disclosed |
| WO-2016187135-A1 | EPIDERMAL NEURAL CREST STEM CELLS AS A SOURCE OF SCHWANN CELLS | SIEBER-BLUM MAYA (US) | 2016-11-24 | — | — | WO | disclosed |
| EP-3039126-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015041809-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2015-03-26 | — | — | WO | disclosed |
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |