Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 19/20 | 0.41 |
| ▸ | RARG | P13631 | 19/20 | 0.41 |
| ▸ | RARA | P10276 | 16/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137833 | 0.94 | RARB (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140796 | 0.92 | RARB (0.48) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7144498 | 0.90 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140394 | 0.82 | RARB (0.40) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7139553 | 0.80 | RARA (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7139558 | 0.80 | RARA (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL18247347 | 0.78 | RARB (0.43) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7701222 | 0.78 | RARB (0.45) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140836 | 0.77 | RARA (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7140832 | 0.77 | RARA (0.50) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | claimed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | claimed |