Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 15/20 | 0.50 |
| ▸ | RARB | P10826 | 15/20 | 0.50 |
| ▸ | RARG | P13631 | 15/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140832 | 1.00 | RARA (0.50) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7139553 | 0.89 | RARA (0.47) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7139558 | 0.89 | RARA (0.47) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL18247318 | 0.86 | GRIK1 (0.40) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL20163299 | 0.86 | RARB (0.53) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7146567 | 0.86 | RARB (0.53) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7137570 | 0.86 | RARB (0.53) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7136936 | 0.84 | RARA (0.44) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7136947 | 0.84 | RARA (0.44) | RARARARBRARGRAB9ANPC1 | |
| SCHEMBL7144498 | 0.83 | RARB (0.50) | RARARARBRARGRXRAHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | claimed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | claimed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | claimed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | claimed |
| US-12104169-B2 | Chemical reprogramming to generate neuronal cells | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2024-10-01 | — | — | US | disclosed |
| US-20220243173-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE | 2022-08-04 | — | — | US | disclosed |
| US-10980778-B2 | Methods for treating multiple osteochondroma (MO) | Clementia Pharmaceuticals Inc. (CA) | 2021-04-20 | — | — | US | disclosed |
| EP-3039126-B1 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J DAVID GLADSTONE INST A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J DAVID GLADSTONE (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20190275005-A1 | METHODS FOR TREATING MULTIPLE OSTEOCHONDROMA (MO) | Clementia Pharmaceuticals Inc. (CA) | 2019-09-12 | — | — | US | disclosed |
| US-20190010451-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE | 2019-01-10 | — | — | US | disclosed |
| EP-3331988-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2018-06-13 | — | — | EP | disclosed |
| US-20180140637-A1 | EPIDERMAL NEURAL CREST STEM CELLS AS A SOURCE OF SCHWANN CELLS | SIEBER BLUM MAYA (US) | 2018-05-24 | — | — | US | disclosed |
| WO-2016187135-A1 | EPIDERMAL NEURAL CREST STEM CELLS AS A SOURCE OF SCHWANN CELLS | SIEBER-BLUM MAYA (US) | 2016-11-24 | — | — | WO | disclosed |
| US-20160250260-A1 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| EP-3039126-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015041809-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2015-03-26 | — | — | WO | disclosed |
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180140637-A1 | EPIDERMAL NEURAL CREST STEM CELLS AS A SOURCE OF SCHWANN CELLS | NES, NCSTN, SOX18 | RARA 519/4885RARB 190/4885RARG 215/4885 |
| US-10980778-B2 | Methods for treating multiple osteochondroma (MO) | UTRN, VHL, SOST | RARA 1990/4885RARB 1620/4885RARG 1720/4885 |
| US-20220243173-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | CHAT, DCX, NES | RARA 29/4885RARB 4/4885RARG 10/4885 |
| US-12104169-B2 | Chemical reprogramming to generate neuronal cells | CHAT, DCX, NES | RARA 29/4885RARB 4/4885RARG 10/4885 |
| US-20190010451-A1 | CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS | CHAT, DCX, NES | RARA 29/4885RARB 4/4885RARG 10/4885 |
| US-20190275005-A1 | METHODS FOR TREATING MULTIPLE OSTEOCHONDROMA (MO) | UTRN, VHL, SOST | RARA 1990/4885RARB 1620/4885RARG 1720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.